Cell Systems· Johannes M. Auth, Inbal Eizenberg-Magar, Omer Erez Dekel, Omer Zachar, Merav D. Shmueli, Inbal Zigdon, Achinoam Shoham, Vladimir Mindel, Tsviya Olender, Meytar Asulin Berrebi, Ariel Tennenhouse, Neta Bar-Hai, Rakefet Ben-Yishay, Dana Ishay-Ronen, Yaron E. Antebi·· 17 小时前AI 评分35
BMP与TGF-β通路间的非对称串扰消解信号歧义
Asymmetric crosstalk between the BMP and TGF-β pathways resolves signaling ambiguity
AI 导读
Auth等发现，细胞通过偏向TGF-β驱动应答的非对称串扰，消解相互对抗的BMP与TGF-β信号之间的歧义。数学建模与实验显示，SMAD异源复合物的非特异性形成将BMP相关介导因子导向TGF-β转录靶标，为整合冲突信号和调控细胞命运提供计算机制。
来源：Cell Systems · cell.com