Cell · In Press· Eric I. Elliott, Tomomi M. Yoshida, Susana C.B.R. Nakandakari, Scott Pope, Cuiling Zhang, Timothy Nottoli, Jae Jin Chae, Daniel L. Kastner, Richard A. Flavell, Vishwa Deep Dixit, Vijay A. Rathinam, Fayyaz S. Sutterwala, Andrew Wang·· 18 小时前AI 评分41
pyrin炎症小体感知OCTN2介导的肌肉损伤或摄食来源细胞外左旋肉碱摄取
The pyrin inflammasome senses OCTN2-mediated uptake of extracellular ʟ-carnitine from muscle injury or ingestion
AI 导读
研究发现，pyrin炎症小体通过高亲和力肉碱转运体OCTN2（SLC22A5）感知细胞外左旋肉碱（ʟ-carnitine），引发IL-1β介导的炎症。结果提示，OCTN2可能成为减轻外源性或内源性细胞外左旋肉碱所致炎症的潜在靶点。
来源：Cell · In Press · cell.com