Cell · In Press· Kojiro Mukai, Dongya Jia, Mamata Panigrahi, Thomas Tayman, Graham Brogden, Ying-Han Chen, Nazmul Haque, Gunjan Arora, Joshua E. Mutterperl, Ian Poe, Chenyu Zhang, Zahin Islam, Ronald Holewinski, Thorkel Andresson, Di Wu, Grzegorz Piszczek, Joseph Marcotrigiano, J. Robert Hogg, Suk See De Ravin, Nasir S. Malik, Avindra Nath, Ekaterina Viktorova, Anna Zimina, George A. Belov, Banu Bayyurt-Kocabaş, Grégoire Altan-Bonnet, Nihal Altan-Bonnet·· 17 小时前AI 评分42
先天免疫感受器应答为病毒复制设定高于单个基因组的输入阈值
Innate sensor responses set a supra-unitary threshold for viral replication
AI 导读
单细胞分析显示，病毒复制需要输入超过单个病毒基因组，且这一阈值因病毒和细胞类型而异。超过单个基因组的病毒基因组数量可在不依赖病毒蛋白合成的情况下，激活RIG-I、MDA-5和PKR的负反馈调节因子，抑制先天免疫应答，从而允许病毒复制。
来源：Cell · In Press · cell.com