Immunity· Evi Paouri, Sarah Stanko, Nadia Gasmi, Gabriele Glusauskas, Valery Mao, Andrew Kwak, Stephanie Hsu, Sahar Sarmadi, Emily Huang, Aniruddha Das, Courtney Hershberger, Quinn Watercutter, Megan R. McMullen, Christopher Birck, Hope Burton, Hale Tobin, Anxhela Gjojdeshi, Julia Dziabis, Richa M. Hanamsagar, Daniel M. Rotroff, Richard A. Prayson, Staci D. Bilbo, Saba Valadkhan, Hod Dana, Laura E. Nagy, Dimitrios Davalos·· 9 天前AI 评分45
小胶质细胞介导的细胞外基质破坏驱动酒精滥用后的神经元功能障碍、运动障碍与镇静
Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments, and sedation following alcohol abuse
AI 导读
Paouri、Stanko等发现，小胶质细胞通过MyD88依赖的突触周围细胞外基质破坏，驱动酒精诱导的镇静、运动障碍及突触和神经元丢失。绕过小胶质细胞、靶向神经元产生同等镇静作用时，细胞外基质未受损。人类酒精使用障碍也存在脑细胞外基质丢失，提示其可能成为区别于神经元干预的治疗靶点。
来源：Immunity · cell.com