Cell Reports Medicine· Kathryn J. Citrano, Vidhya Bharathi Maheswari Jawahar, Madison M. Reeves, Leonardo Petrucelli, Yari Carlomagno, Mei Yue, Jorge Alaiz Noya, Lillian M. Daughrity, Raul Baena Tomé, Karen Jansen-West, Bailey Rawlinson, Michael DeTure, Erica Engelberg-Cook, Alpana Singh, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, Adam L. Boxer, David S. Knopman, Keith A. Josephs, Ronald C. Petersen, Björn Oskarsson, Nicholas J. Ashton, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Yong-Jie Zhang, Leonard Petrucelli·· 8 天前AI 评分43
抗HDGFL2隐匿蛋白抗体可灵敏反映TDP-43病理及临床疾病特征
Anti-HDGFL2 cryptic protein antibodies provide a sensitive readout of TDP-43 pathology and clinical disease features
AI 导读
Citrano、Maheswari Jawahar等开发了针对HDGFL2-CE蛋白的灵敏免疫测定，发现脑组织中该蛋白水平与pTDP-43病理相关。该测定采用第二代多克隆及单克隆抗体；在FTLD-TDP及FTLD-TDP/MND患者中，该蛋白水平还与更早出现症状及更短生存期相关。
来源：Cell Reports Medicine · cell.com