Cell Reports Medicine· Kristoffer Haurum Johansen, Keerthana Ramanathan, Carlos Rodriguez-Pardo, Anne Kargaard Gjelstrup, Hólmfridur Rósa Halldórsdóttir, Lasse Frank Voss, Siri Tvingsholm, Laura Stentoft Grand, Edoardo Dionisio, Alberte H. Skriver, Louise Pii Frederiksen, Mette Bjørnson, Marcus Svensson-Frej, Maria Ormhøj, Sine Reker Hadrup·· 19 小时前AI 评分35
抗原支架促进具有功能的基因工程CAR和TCR T细胞优先扩增
Antigen scaffolds drive preferential expansion of functional genetically engineered CAR and TCR T cells
AI 导读
Johansen、Ramanathan等开发的人工抗原支架可促进经CRISPR或慢病毒工程改造的CAR或TCR T细胞扩增，使其呈现增殖和高度细胞毒性特征。该支架呈递相应抗原、IL2和IL21；研究背景是采用CRISPR-Cas9制造T细胞疗法时，终末分化的基因敲入T细胞比例较低。
来源：Cell Reports Medicine · cell.com