Immunity· Marina Terekhova, Maksim Kleverov, Thomas Francis, Dmitrii Usoltsev, Pavla Bohacova, Laura Arthur, Petr Tsurinov, Denis Kleverov, Luke Trinity, Kamila Husarcikova, Ivan Molotkov, Titas Grabauskas, Amir Fathi, Eloise Milbourn, Esme Newton, Leah Siegel, Adnaan Ghanchi, Urika Tse, Ross D. Pollock, Niharika A. Duggal, Janet M. Lord, Norman R. Lazarus, Ali H. Ellebedy, Duygu Ucar, Stephen D.R. Harridge, Mykyta Artomov, Maxim N. Artyomov·· 8 天前AI 评分45
全球队列单细胞分析勾勒免疫衰老决定因素，并揭示GZMK+与GZMB+ Tem细胞比值与健康轨迹的关联
Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories
AI 导读
Terekhova等通过全球队列单细胞分析发现，CD8+ Tem细胞中GZMK+与GZMB+的比值可区分健康与疾病相关衰老轨迹，并预测死亡风险。研究整合8个数据集、2,609名个体及超过1200万个细胞，构建PBMC图谱，解析人类免疫衰老的可变与保守特征。
来源：Immunity · cell.com