Immunity· Felipe Batista Leão, Dev Bhatt, Lauren Vaughn, Will Liao, Dillon Maloney, Vincent Guichard, Brea Hampton, Alexander Yang, Thomas S. Postler, Ruxiao Yang-Fischer, Jingyao Zhao, Donna Farber, Sankar Ghosh·· 19 小时前AI 评分38
NF-κB 磷酸化通过控制增强子选择塑造炎症基因表达程序
NF-κB phosphorylation controls enhancer selection to shape the inflammatory gene program
AI 导读
Leão等发现，NF-κB的p65亚基Ser276磷酸化促进CBP/p300募集，使潜伏增强子得以参与并被激活。这一增强子选择机制控制特定的基因表达程序，塑造炎症和抗微生物免疫应答。
来源：Immunity · cell.com