Cell Metabolism· Zexu Wei, Ranran Yu, Junnan Xu, Chenyu Tao, Aixia Zhang, Longjie Li, Xiaoshan Zhang, Jin He, Jiajun Yu, Xuhuang Xiao, Jiahui Guo, Tong Wang, Wei Gong, Yanbo Wang, Chen-Yu Zhang, Dijun Chen, Zhang-Peng Chen, Chenbo Ji, Xi Chen·· 19 小时前AI 评分38
产后抑郁相关母乳细胞外囊泡介导对子代神经发育的代际影响
Postnatal depression-associated breastmilk extracellular vesicles mediate intergenerational effects on offspring neurodevelopment
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母体产后抑郁使母乳小细胞外囊泡中的特定微小RNA富集，经哺乳传递至子代下丘脑，介导神经发育的代际影响。这些微小RNA抑制投射至海马的神经元中的mGluR8，扰乱钙活动及新生神经元整合，导致持续至成年期的认知和情绪缺陷。
来源：Cell Metabolism · cell.com