Cell · In Press· Luca Posa, Giovanna R. Romano, Xiang Ji, Saif Khan, Antonina L. Nazarova, Sheida Sharghi Moshtaghin, Bruno Paz, Gye Won Han, Anisul Arefin, Alberto J. Gonzalez-Hernandez, Ipsit Srivastava, Saheem A. Zaidi, Kenny Calderon-Godinez, Zixin Zhang, Aaliyah S. Tyson, Mohsen Ranjbar, Kristen E. Pleil, Kanupriya Pande, Vsevolod Katritch, Cornelius Gati, Dirk Trauner, Joshua Levitz·· 2 天前AI 评分40
Azo-morphine-3：用于可逆光控镇痛的阿片效能开关
An opioid efficacy switch for reversible optical control of analgesia
AI 导读
光开关配体Azo-morphine-3（AM-3）可在低效能与高效能状态间切换，实现对镇痛的可逆光控。AM-3可在体外及体内调控脑和外周的μ阿片受体活性，在多种疼痛模型中实现时空精准镇痛，且较全身用药副作用更少。
来源：Cell · In Press · cell.com