Cancer Cell· Kotaro Nomura, Tomoyo Fukami, Shinichiro Kato, Shunya Tanaka, Akito Fukuda, Yuki Koike, Masaki Kondo, Kazuhiro Kumagai, Takuma Irie, Genki Okumura, Tetsuro Taki, Shingo Sakashita, Masayuki Shirasawa, Tatsuya Yoshida, Kouya Shiraishi, Ryo Ariyasu, Yuki Takeyasu, Takahiro Niimi, Tetsuya Sakai, Masahiro Torasawa, Hiroaki Kanemura, Shin Saito, Takuo Hayashi, Akinori Kanai, Kazuya Takamochi, Tomohiro Haruki, Keiju Aokage, Hitomi Nishinakamura, Shohei Koyama, Genichiro Ishii, Yutaka Suzuki, Yasushi Goto, Makoto Nishio, Kenji Suzuki, Yasuhiro Tsutani, Yasushi Yatabe, Hiroyuki Mano, Masahiro Tsuboi, Shogo Kumagai, Hiroyoshi Nishikawa·· 19 小时前AI 评分43
肺神经内分泌癌通过血清素诱导免疫抑制性巨噬细胞，驱动对T细胞衔接器tarlatamab的耐药
Lung neuroendocrine cancer induces immunosuppressive macrophages via serotonin to drive resistance to the T cell engager tarlatamab
AI 导读
Nomura等发现，肺神经内分泌癌通过肿瘤来源的血清素诱导免疫抑制性巨噬细胞，驱动对T细胞衔接器及免疫检查点阻断治疗的耐药。在小细胞肺癌和大细胞神经内分泌癌中，血清素通过HTR7信号抑制抗肿瘤T细胞反应，限制免疫治疗疗效，并揭示潜在治疗靶点。
来源：Cancer Cell · cell.com