Immunity· Ervin Ascic, Camille Chatelain, Gaia Fontanari, César Pérez Bucio, Linmeng Zhang, Maria Thrasyvoulou, Viktoria Karali, Tommaso Ballocci, Maria de Rosa Torres, Simon Rabreau, Katherine Hampton, Martin Lauss, Bengt Phung, Fritiof Åkerström, Arun Kumar Sundaramurthy, Xavier Catena, Chaofan Fan, Stevanus Jonathan, Anna Darabi, Johan Bengzon, Fábio F. Rosa, Göran B. Jönsson, Ilia Kurochkin, Carlos-Filipe Pereira·· 20 小时前AI 评分47
肿瘤细胞向树突状细胞重编程可在多种癌症中诱导免疫原性淋巴样结构
Tumor-to-dendritic cell reprogramming induces immunogenic lymphoid structures across cancers
AI 导读
Ascic、Chatelain等建立了肿瘤细胞向cDC1重编程的策略，可在多种癌症中生成具有免疫原性的三级淋巴样结构。研究揭示，局部迁移性cDC1与依赖CD40的T细胞相互作用，协调局部及全身的细胞免疫和体液免疫。
来源：Immunity · cell.com