Cell · In Press· Sydnye L. Shuttleworth, Michael A. Bauer, Dennis W. Province, Jessica L. Kelliher, Nicole E. Scharping, Alexander Monell, Lora J. Rogers, Thomas A. Williams, Grant T. Dawson, Katherine F. Wallis, Duah Alkam, Jacob L. Edmondson, Daniel Fil, Aaron J. Storey, Anna L. Bolding, Rick D. Edmondson, Stephanie D. Byrum, Karen E. Beenken, Samuel G. Mackintosh, Ananda W. Goldrath, Alan J. Tackett, Brian Koss·· 17 小时前AI 评分42
T细胞耗竭蛋白质组图谱揭示蛋白质稳态崩溃
Proteomic atlas of T cell exhaustion defines proteostatic collapse
AI 导读
人类T细胞耗竭多组学图谱揭示，功能障碍T细胞的蛋白质周转和泛素调控发生广泛重塑，而转录组分析未能捕捉这些变化。E3泛素连接酶RNF166调控T细胞的持久性及抗肿瘤功能，提示蛋白质稳态可能成为改善免疫治疗的可靶向轴。
来源：Cell · In Press · cell.com