Cell Reports Medicine· Yuanqin Zhang, Xia Liu, Yixuan Xie, Lei Zhao, Myung Sik Jeon, Lisha Ai, Jingqin Luo, David A. Ford, Hazar Abusalamah, R. Alex Harbison, Cody Huffman, Jialin Guo, Iris He, Allison Mulvehill, Craig A. Buchman, Sidharth V. Puram, Benjamin A. Garcia, Mark A. Varvares, Marco Colonna, Guangyong Peng·· 19 小时前AI 评分43
肿瘤微环境中的衰老T细胞是驱动肿瘤生长、干性和化疗耐药的重要因素
Senescent T cells within the tumor microenvironment are a potent driver for tumor growth, stemness, and chemotherapy resistance
AI 导读
Zhang等发现，衰老T细胞在肿瘤内积聚，并驱动肿瘤生长、转移、干性和化疗耐药。其富含脂质的衰老相关分泌表型重编程肿瘤脂质代谢，并激活STAT1/STAT3信号。靶向衰老T细胞或其与肿瘤细胞的代谢串扰可抑制肿瘤进展、增强治疗效果。
来源：Cell Reports Medicine · cell.com