Cell · In Press· Hannah N. Bell, Kavya Nair, Kole Tison, Peng Liao, Hongwei Lei, Marwa O. El-Derany, Ayijiang Yisimayi, Haiwei Zhang, Ryan Rebernick, Weichao Wang, Yoshitaka Adachi, Cristina Castillo, Nupur K. Das, Jinsu An, Vivien R. Sutton, Xun Lin, Heng Lin, Xinghao Wang, Yunfei Li, Linda Vatan, Amr Aboud, Shuang Wei, Miguel Gijon, Samantha Goodwin, Yatrik M. Shah, Ilona Kryczek, Joseph A. Trapani, Margarida Barroso, Judy Lieberman, Weiping Zou·· 19 小时前AI 评分42
穿孔素触发铁诱导的线粒体损伤，驱动铁死亡与抗肿瘤免疫
Perforin triggers iron-induced mitochondrial damage to drive ferroptosis and anti-tumor immunity
AI 导读
研究发现，穿孔素可通过不依赖颗粒酶的途径促进铁摄取及线粒体铁过载，触发铁死亡，发挥独立的杀伤作用。这一途径将细胞毒性免疫与铁代谢相联系，可预测患者对免疫检查点阻断治疗的反应，并提示补铁可能有助于增强抗肿瘤免疫。
来源：Cell · In Press · cell.com