Cell · In Press· Shuke Xiao, Alan Sheng-Hwa Tung, Jan Spaas, Sipei Fu, Xudong Chen, Tuan Kiet Trinh, Maria Dolores Moya-Garzon, Veronica L. Li, Hannah T. Cessna, Kentaro Ito, Saranya C. Reghupaty, Chao Lin, Xuchao Lyu, Steffen H. Raun, Miles D.W. Tyner, Arthur Germakovski, Jacob Tondreau, Megan Yeckley, Wei Wei, Michael R. Howitt, Mark D. Parker, Jason A. Sprowl, Stephen M. Hinshaw, Jonathan Z. Long·· 19 小时前AI 评分47
MCT6是二甲双胍相关体重减轻所必需的肠道Lac-Phe外排转运体
MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss
AI 导读
MCT6介导肠道细胞将Lac-Phe外排入血，小鼠研究显示其是二甲双胍（metformin）相关体重减轻所必需的转运体。肠道缺失MCT6的小鼠无法维持正常循环Lac-Phe水平，且对二甲双胍相关体重减轻表现出抵抗，提示代谢物外排是调控其全身作用的节点。
来源：Cell · In Press · cell.com