Cell Reports Medicine· Jiao Hu, Yifan Liu, Minfeng Chen, Jiantu Ou, Tongchen He, Jinhui Liu, Minghui Hu, Bohan Zhou, Huihuang Li, Luzhe Yan, Jiatong Xiao, Zhenyu Nie, Zhiyong Cai, Peihua Liu, Dingshan Deng, Yunbo He, Benyi Fan, Zhenyu Ou, Ruizhe Wang, Guanghui Gong, Xiao Guan, Shiyu Tong, Yangle Li, Wei He, Zefu Liu, Yuanqing Dai, Bolong Liu, Xiaogen Kuang, Tao Guo, Lunquan Sun, Xiaohua Yao, Junhao Yu, Hengyun Wang, Jinbo Chen, Xiongbing Zu·· 19 小时前AI 评分42
膀胱癌新辅助免疫治疗期间肿瘤微环境的时空动态演变
Spatiotemporal dynamic evolution of the tumor microenvironment during neoadjuvant immunotherapy for bladder cancer
AI 导读
Hu等描绘了膀胱癌新辅助免疫治疗期间微环境的表型演变，发现治疗驱动肿瘤细胞走向不同命运。治疗还建立了免疫治疗诱导的肿瘤-髓系屏障，促进T细胞终末耗竭，并诱导衰老性iCAF表型。SERPINH1可能成为针对获得性耐药的治疗靶点。
来源：Cell Reports Medicine · cell.com