Cell · In Press· Dipyaman Patra, Katelyn Wolfgang, Chenxian Ye, Lora Rigatti, Kelsey Ertwine, Kristin M. Morder, Jessica Jana, Ishita Baral, Drew Hurd, Kaitlin Bossong, Steven Mullett, Yingtong Dou, Stacy Gelhaus, Dario A.A. Vignali, Diwakar Davar, Anthony R. Cillo, Greg M. Delgoffe, Abigail E. Overacre-Delgoffe·· 19 小时前AI 评分42
生活方式诱导的调节性T细胞脆弱性增加免疫检查点阻断后不良事件易感性
Lifestyle-induced regulatory T cell fragility primes adverse events after immune checkpoint blockade
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饮食与微生物改变通过促进IFN-γ驱动的调节性T细胞脆弱性及细胞毒性组织驻留T细胞反应，增加免疫相关不良事件易感性。特异性阻断调节性T细胞的IFN-γ信号可恢复组织稳态、减少免疫相关不良事件，且不损害抗肿瘤免疫，提示维持其稳定性可能是限制免疫检查点阻断毒性的治疗策略。
来源：Cell · In Press · cell.com