Cell · In Press· Zijian Pan, Ming-Kwan Wong, Yang Lu, Jingxuan Mao, Fengxiang Wang, Xin Gu, Kaiyin Huang, Taotao Shi, Tianshu William Wu, Yuxuan Zhu, Yuan Zhang, En Chen, Jingrong Regina Han, Yunfei Qiu, Lei Zhou, Yinxin Li, Peng Lin, Zhibin Li, Shan Deng, Yingshan Fang, Qi Xie, Jian Cao, Nathchar Naowarojna, Dan Yang, Yilong Zou·· 2 天前AI 评分41
线粒体靶向四氧烷启动脂质过氧化，驱动铁死亡并抑制肿瘤
Mitochondria-targeted tetraoxanes initiate lipid peroxidation to drive ferroptosis and tumor suppression
AI 导读
Pan等发现，含四氧烷的化合物WMK-1/2可诱导线粒体脂质过氧化，并在多个体内模型中表现出强效肿瘤抑制活性。此类化合物可绕过GPX4和视黄醇介导的防御，触发一种独特的“线粒体铁死亡”亚通路。
来源：Cell · In Press · cell.com