Cell · In Press· Nathchar Naowarojna, Xin Gu, Zijian Pan, Jun Yu, Kaiyin Huang, Yuyang Zeng, Yuheng Xie, Yuan Zhang, Fengxiang Wang, Jingxuan Mao, Yanxiong Yu, Tianshu William Wu, Jinshi Yu, Shi’en Liu, Senhao Xiao, Lijie Bai, Dongqi Li, Zhenkun Wu, Caiyi Wei, Qiu Li, Hongqing Yao, Xiaoxiao Zhang, Yupan Li, Guanglei Xie, Lei Gao, Jinheng Pan, Lijun Wang, Jin Hu, Xuefei Feng, Qin Peng, Shan Feng, Xi Wang, Yuqi Wang, Tao Peng, Yikai Wang, Yilong Zou·· 17 小时前AI 评分41
可在体内诱导铁死亡并抑制肿瘤的生物可利用性 GPX4 抑制剂 KY0418
A bioavailable GPX4 inhibitor for ferroptosis induction in vivo and tumor suppression
AI 导读
研究开发了具有生物可利用性的 GPX4 抑制剂 KY0418，可在体内诱导铁死亡，并在特定情境下抑制肿瘤进展，包括转移扩散。研究还将全身性铁死亡诱导与组织代谢重塑联系起来。
来源：Cell · In Press · cell.com