Cell Reports Medicine· Yueyue Fan, Jiamin Ye, Yuanfang Chen, Gaoli Niu, Mengbin Ding, Ruiyan Li, Li Wang, Yong Kang, Xiangyang Yu, Xiaoyuan Ji·· 19 小时前AI 评分37
工程化肝细胞微纳机器人通过糖异生靶向清除乳酸，实现放疗增敏与免疫激活
Targeted lactate depletion via gluconeogenesis by engineered hepatocyte-based micronanorobots for radiosensitization and immune activation
AI 导读
Fan等开发了整合Au-Pt纳米机器人的CXCR4工程化肝细胞去核细胞体，通过糖异生清除肿瘤乳酸，实现放疗增敏与免疫激活。乳酸清除抑制修复相关乳酰化并削弱MRN介导的DNA修复，Au-Pt催化则增强辐射诱导的损伤。这种代谢重塑同时缓解免疫抑制，促进全身抗肿瘤免疫。
来源：Cell Reports Medicine · cell.com