Immunity· Carlos Luri-Rey, Inmaculada Rodríguez, Saioa Arrieta-Aranzueque, David Ruiz Guillamón, Enric Vercher, Nekane Soria, Paula Molero-Glez, Raquel Cuesta, Gabriel Gomis, Arantza Azpilikueta, Elixabet Bolaños, Almudena Manzanal, Saray Garasa, Tsuneyasu Kaisho, Raluca Alexandru, Paulo Pérez Domínguez, Alfonso Calvo, Francisco Exposito, Ignacio Heras-Murillo, David Sancho, Michela Capello, Nora Pencheva, Pedro Berraondo, Carlos de Andrea, Maria Jure-Kunkel, Álvaro Teijeira, Ignacio Melero·· 18 小时前AI 评分36
PD-L1+ 1型常规树突状细胞介导的T细胞交叉启动介导PD-L1×4-1BB双特异性抗体的抗肿瘤疗效
T cell cross-priming by PD-L1+ type 1 conventional dendritic cells mediates the antitumor efficacy of a PD-L1×4-1BB bispecific antibody
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Luri-Rey等发现，PD-L1×4-1BB双特异性抗体的抗肿瘤疗效依赖表达PD-L1的1型常规树突状细胞。这些细胞整合抗原交叉呈递、IL-12及4-1BB共刺激，促进T细胞介导的抗肿瘤免疫；此类抗体正处于临床开发阶段。
来源：Immunity · cell.com