Cell Metabolism· Suyao Li, Dong Guo, Qingqing Yang, Yizhi Cao, Yu Dong, Xiaoming Jiang, Xinyao Tian, Dou Nie, Lihui Wu, Qingang Wu, Xuxiao He, Yanyan Hu, Rongxuan Zhu, Ning Zhu, Shudi Luo, Yinan Shen, Yuhao Wang, Zhexu Chi, Ying Yuan, Daqian Xu, Weilin Wang, Yuan Ding, Zhimin Lu·· 17 小时前AI 评分40
丙酸促进 MHC I 类抗原呈递和抗肿瘤免疫
Propionate promotes MHC class I antigen presentation and anti-tumor immunity
AI 导读
Li等发现，丙酸通过结合E3连接酶STUB1，阻断MHC I类分子的泛素化与降解，增强肿瘤抗原呈递。这一非代谢功能促进CD8+ T细胞免疫并增强抗PD-1疗效，支持将膳食丙酸或产丙酸益生菌作为改善癌症免疫治疗的潜在策略。
来源：Cell Metabolism · cell.com