Cell Reports Medicine· Qing Zhang, Simeng Li, Mengting Xu, Hanchi Xu, Haiyang Zhou, Hongmei Hu, Dianping Yu, Linyang Li, Xiaoyu Tao, Xuwen Lin, Xinru Li, Shize Xie, Xinying Xue, Qun Wang, Tao Yang, Weidong Zhang, Sanhong Liu·· 18 小时前AI 评分34
异补骨脂查尔酮（isobavachalcone）靶向去泛素化酶 OTUB1，诱导 PD-L1 降解并增强抗肿瘤免疫
Isobavachalcone targets deubiquitinase OTUB1 to induce PD-L1 degradation and enhances antitumor immunity
AI 导读
Zhang 等发现，异补骨脂查尔酮（isobavachalcone）靶向去泛素化酶 OTUB1，促进癌细胞中 PD-L1 的泛素化与降解。这一调控增强 T 细胞介导的抗肿瘤免疫，并重塑肿瘤免疫微环境，抑制肿瘤生长。
来源：Cell Reports Medicine · cell.com