Cancer Cell· Anthony R. Sloan, George Bukenya, Gavin P. Tannish, Daniel J. Silver, Anu Aggarwal, Juyeun Lee, Daniel Rosoff, Tyler J. Alban, Ivan Juric, Shikha Parsai, Vargab Baruah, Tyler Bodovetz, Donovan Whitfield, Liza Tack, Tanvi Navadgi, Natalie Reitz, Shawn T. Ho, Aarav Badani, Jessica Goldberg, Xueer Yuan, Aymerick Gaboriau, Samrutha Kamatala, Jesse Coker, Vrishabhadev Sathish Kumar, Saachi S. Jain, Chang Xu, Alliefair Scalise, Bhairavi Rajasekar, Alex Vincenti, Erin E. Mulkearns-Hubert, Craig M. Horbinski, Andrew E. Sloan, Christopher G. Hubert, Jingqin Luo, Joshua B. Rubin, Evi X. Stavrou, Falk W. Lohoff, Wendy A. Goodman, Tyler E. Miller, Christine M. O’Connor, Marvin T. Nieman, Naseer Sangwan, Timothy A. Chan, Alok A. Khorana, Andrew Dhawan, Scott J. Cameron, Justin D. Lathia·· 17 小时前AI 评分37
性别特异性血小板开关调控胶质母细胞瘤的抗肿瘤免疫
A sex-specific platelet switch controls anti-tumor immunity in glioblastoma
AI 导读
Sloan等发现，血小板通过PAR4信号抑制胶质母细胞瘤的抗肿瘤免疫，阻断PAR4可选择性使女性获益。这一作用通过增强雌激素受体β依赖的CD8+ T细胞应答实现，揭示了连接血栓形成、性别差异与免疫治疗的机制。
来源：Cancer Cell · cell.com