Cell Metabolism· Xingyu Zhou, Chuanfa Liu, Wenchao Wei, Xueliang Wang, Yasi Pan, Ying Jiao, Shiyu Li, Yating Zhang, Harry Cheuk-Hay Lau, Ruyi Zhang, Dingwu Li, Alvin Ho-Kwan Cheung, Minghua Zheng, Wen Pan, Chi Chun Wong, Vincent Wai-Sun Wong, Jun Yu, Xiang Zhang·· 15 天前AI 评分43
米根霉通过产生犬尿喹啉酸促进代谢功能障碍相关脂肪性肝病相关肝细胞癌
Fungus Rhizopus arrhizus promotes MASLD-associated hepatocellular carcinoma through generating kynurenic acid
AI 导读
Zhou等发现，肠道真菌米根霉（Rhizopus arrhizus）通过产生犬尿喹啉酸，促进代谢功能障碍相关脂肪性肝病相关肝细胞癌（MASLD-HCC）。犬尿喹啉酸直接结合肿瘤细胞并激活致癌性MAPK信号，阻断这一宿主与真菌的相互作用可抑制MASLD-HCC发生发展。
来源：Cell Metabolism · cell.com