Cancer Cell· Carla Pallarés-Moratalla, Mélanie Guyot, Krish Skandha Gopalan, Bernhard Robl, Jakub Idkowiak, Jonas Dehairs, Nina Ravoet, Tim F.E. Hendriks, Kinga Anna Nowak, Nikolina Dubroja Lakić, Linqian Weng, Vasileios Konstantakos, Xander Spotbeen, Lutgarde Serneels, Sarah-Maria Fendt, Stein Aerts, Frederik De Smet, Eva Cuypers, Johannes V. Swinnen, Gabriele Bergers·· 19 小时前AI 评分43
巨噬细胞脂质信号驱动胶质母细胞瘤侵袭，并构成潜在治疗靶点
Macrophage lipid signaling drives glioblastoma invasion and represents a therapeutic vulnerability
AI 导读
Pallarés-Moratalla等发现，胶质母细胞瘤通过脂质介导的旁分泌回路促进侵袭，阻断该回路可抑制肿瘤浸润。肿瘤细胞经CSF1R-PI3K重编程肿瘤相关小胶质细胞/巨噬细胞，诱导其分泌溶血磷脂酰胆碱并转化为促侵袭的溶血磷脂酸，提示改善手术结局的潜在治疗策略。
来源：Cancer Cell · cell.com