Immunity· Jiemeng Fu, Siyu Pei, Jiadan Du, Xiuyu Deng, Xindong Wang, Tong Li, Huan Huang, Jialin Ye, Jing Xu, Xueqing Wang, Youwei He, Yu Li, Yitong Sun, Yuan Wang, Ji-Hong Yang, Jing-Hua Li, Dongfang Dai, Yichuan Xiao·· 16 天前AI 评分39
葡萄糖匮乏的肿瘤微环境激活AMP活化蛋白激酶，驱动过继转移的辅助性T细胞9衰老
Glucose-deprived tumor microenvironment activates AMP-activated protein kinase to drive adoptively transferred T helper 9 cell senescence
AI 导读
Fu等发现，葡萄糖匮乏通过激活Th9细胞的AMPK-ZAK-NIK轴，抑制IL-9分泌，触发细胞衰老并削弱其持存能力。靶向ZAK可使Th9细胞恢复活力，从而增强基于CAR-Th9的疗法对实体瘤的抗肿瘤效力。
来源：Immunity · cell.com