Cell Reports Medicine· Lexuan Wang, Yang Chen, Yanyu Shang, Jia Liu, Muyuan Zhao, Lei Jin, Yichenxi Shi, Ruili Zhang, Zhuang Chen, Ting Yin, Chaoqiang Qiao, Zhongliang Wang·· 5 天前AI 评分41
口服代谢重编程益生菌级联激活结直肠癌抗肿瘤免疫
Orally delivered metabolically reprogrammed probiotics for cascade-activated antitumor immunity in colorectal cancer
AI 导读
Wang等开发口服代谢工程细菌平台EcN-HlpA-CGL [EHC]，激活抗肿瘤免疫并有效抑制结直肠癌原位肿瘤生长和转移。该平台诱导癌细胞铁死亡以增强免疫原性，并借助细菌佐剂作用重塑免疫抑制微环境，同时激活全身及肠黏膜免疫。
来源：Cell Reports Medicine · cell.com