Cancer Cell· Tao Wang, Junyu Xiang, Shuoran Tian, Xiangming Wang, Zhaole Chu, Zailiang Yang, Weiwu Gao, Xianfeng Li, Biying Liu, Qiang Ma, Zengjie Lei, Xiaochun Shen, Yinbin Zhou, Lei Wang, Linghong Wan, Quanyou Zheng, Wenkang Liu, Jinyang Li, Linyu Wu, Yongying Hou, Xipeng Zheng, Huilin Pan, Shixin Qin, Qin Liu, Mengting Sun, Xu Chen, Fanxuan Tian, Xiao Hu, Ziyi Peng, Zhaoyang Zhong, Chuan Chen, Fan Li, Shunan Wang, Dongfeng Chen, Liangzhi Wen, Ke Li, Qiaoqiao Zhang, Cheng Lin, Zhongyi Qin, Zhifeng Miao, Xiu-Wu Bian, Zhenning Wang, Fan Bai, Bin Wang·· 11 天前AI 评分47
染色质可及性轨迹揭示癌前表观遗传预激状态及酸驱动的免疫治疗耐药胃癌亚型
Chromatin accessibility trajectories reveal pre-cancerous epigenetic priming and an acid-driven immunotherapy-resistant gastric cancer subtype
AI 导读
Wang等构建650份胃组织样本的染色质可及性图谱，揭示化生中的癌样表观遗传预激状态及酸驱动的免疫治疗耐药胃癌亚型。晚期胃癌分为三种表观基因组亚型，其中拟胃型通过FOSL2驱动H+/K+ ATPase表达，使微环境酸化并抑制CD8+ T细胞；伏诺拉生（vonoprazan）可逆转这一表型。
来源：Cancer Cell · cell.com