Cancer Cell· Anguraj Sadanandam, Alice C. O’Farrell, Ian S. Miller, P.S. Hari, Adrian Lärkeryd, Tom Venken, Ingrid Arijs, Eugenia R. Zanella, Francesca Cottino, Marika Pinnelli, Valentina Vurchio, Elena Grassi, Aoife Nolan, Niraj Khemka, Michael Fichtner, Gift Nyamundanda, Zak Kinsella, Maxime Meylan, Liam P. Shiels, Colum Connolly, Janick Selves, Nadja M. Meindl-Beinker, Raquel Comas Navarro, Elena Elez, Frank A. Lincoln, Chanthirika Ragulan, Orla Casey, Verena Murphy, Josep Tabernero, Walter Kolch, Matthias P. Ebert, Raquel Perez-Lopez, Florence Monville, Dirk Fey, Joern Lewin, Jonathan Briody, Kathleen Bennett, Enrique J. Arenas, Joaquín Arribas, David Matallanas, Darran P. O’Connor, Alexander Kel, Catherine Sautès-Fridman, Wolf H. Fridman, Bart Ghesquière, Paolo Nuciforo, Diether Lambrechts, Livio Trusolino, Jochen H.M. Prehn, Rodrigo Dienstmann, Annette T. Byrne, the COLOSSUS consortium·· 19 小时前AI 评分46
微卫星稳定型结直肠癌的多组学表征揭示独特生物学特征与可靶向弱点
Multiomic characterization of microsatellite-stable colorectal cancer reveals distinct biology and targetable vulnerabilities
AI 导读
Sadanandam等整合∼2,000例结直肠癌肿瘤的多组学、单细胞及临床数据，揭示微卫星稳定型结直肠癌的生物学特征与潜在治疗靶点。关键特征包括复制应激、右侧定位、谷氨酰胺分解及MYC-E2F相关表观遗传程序；抑制FAK、PDK1/2或蛋白酶体并联合曲美替尼（trametinib）是潜在治疗策略。
来源：Cancer Cell · cell.com