Cell Metabolism· Taisuke Kondo, Makoto Ando, Josquin Moraly, Justyn DuSold, Abdallah Abdelmaksoud, Hannah W. Song, Lakshmi Balagopalan, Dongya Jia, Laetitia Racine, Andy D. Tran, Sooraj Achar, Serifat O. Adebola, Pedro Gonzalez-Menendez, John Buckley, Anjali Chandroth, Alka Dwivedi, Nikolaos Svoronos, Angela Su, Christopher D. Chien, Alexander D. Clark, Xiyuan Zhang, Bonnie Yates, King Chan, Stephen D. Fox, Xia Xu, Nicholas P. Restifo, Neeraja Syed, Michael C. Kelly, Michael Kruhlak, Yuki Kagoya, Rémy Bosselut, Jack F. Shern, Thorkell Andresson, Valérie Dardalhon, Craig J. Thomas, Steven L. Highfill, Nirali N. Shah, Grégoire Altan-Bonnet, Naomi Taylor·· 18 小时前AI 评分47
精氨酸重塑 eIF4F 翻译起始，克服发热诱导的 CAR T 细胞功能障碍
Arginine rewires eIF4F translation initiation to overcome fever-induced CAR T cell dysfunction
AI 导读
Kondo等发现，精氨酸可恢复高热下CAR T细胞的翻译与效应功能，儿童白血病患者的发热负担与CAR T细胞应答减弱相关。研究揭示，高热诱导的代谢瓶颈将精氨酸代谢受损与翻译功能障碍相联系，精氨酸的益处还延伸至体内补充和临床CAR T细胞制备。
来源：Cell Metabolism · cell.com