早期胚胎程序在癌症中广泛表达,其与生存的关联取决于胚胎发育阶段
Pervasive expression of early embryonic programs in cancer has stage-dependent survival impact
肿瘤的早期胚胎转录相似性与总生存期相关,关联方向因胚胎阶段及表达细胞群而异。
单细胞、空间组学、多组学、GWAS 与孟德尔随机化、机器学习:看清数据从哪来、分析流程怎么走、用了哪些工具。
Pervasive expression of early embryonic programs in cancer has stage-dependent survival impact
肿瘤的早期胚胎转录相似性与总生存期相关,关联方向因胚胎阶段及表达细胞群而异。
Auxiliary modalities add no detectable discrimination or calibration over structured EHR for 30-day COPD readmission: evidence from a leakage-audited MIMIC-IV cohort
经时间泄漏校正与再校准,多模态融合预测 COPD 30 天再入院未优于单独结构化 EHR。
Multi-omics atlas of chronic exercise.
在小鼠中,长期运动引起组织、性别和昼夜时相特异的分子重塑,单核多组学揭示细胞类型特异变化。
Metabolomic aging and mortality clocks based on ensemble learning identify systemic aging risk across the human life span in 18,476 individuals.
代谢组年龄加速与健康恶化、慢性病发生及全因死亡风险升高相关。
Early detection of gastric cancer using DNA features in red blood cells, with multicenter validation.
红细胞DNA特征分类器在多中心验证中检测胃癌的敏感度为83%-90%,I期为82%-89%。
Characterisation of Genetically-Derived Patient Clusters Highlights Genetic Heterogeneity of Inflammatory Bowel Disease
3个IBD队列中,NOD信号通路基因聚类与疾病亚型、克罗恩病行为及手术史相关,主要关联来自NOD2。
Deep learning-enabled screening of chronic kidney disease from echocardiography.
超声心动图深度学习模型可识别慢性肾脏病,在两个独立外部队列中保持稳健表现。