单细胞、空间组学、多组学、GWAS 与孟德尔随机化、机器学习：看清数据从哪来、分析流程怎么走、用了哪些工具。
High-resolution diffusion MRI of rectal cancer ex vivo surgical specimens reveals post-treatment microstructural characteristics of tissue components
直肠癌治疗后离体标本中，扩散MRI指标与组织成分差异相关，可提供常规对比之外的微结构信息。
Metabolome and microbiome analysis of human milk from women with lactational mastitis during remission
哺乳期乳腺炎缓解期与乳汁脂质谱异常相关，但菌群多样性与对照无显著差异。
Pervasive expression of early embryonic programs in cancer has stage-dependent survival impact
肿瘤的早期胚胎转录相似性与总生存期相关，关联方向因胚胎阶段及表达细胞群而异。
Nearly half of reef-building corals face elevated relative risk of extinction.
重新评估发现，数据充分的774种造礁珊瑚中，340种（44%）被列为受威胁物种。
Auxiliary modalities add no detectable discrimination or calibration over structured EHR for 30-day COPD readmission: evidence from a leakage-audited MIMIC-IV cohort
经时间泄漏校正与再校准，多模态融合预测 COPD 30 天再入院未优于单独结构化 EHR。
Multi-omics atlas of chronic exercise.
在小鼠中，长期运动引起组织、性别和昼夜时相特异的分子重塑，单核多组学揭示细胞类型特异变化。
Exome-wide rare variant genetic load is associated with cognition, intellectual disability and psychiatric disorders in population-based cohorts
人群队列中，基因约束加权的罕见变异遗传负荷与较低认知及多种神经精神障碍相关。
A phenome-wide structural variant map from 467,152 UK Biobank genomes.
在467,152名参与者中，结构变异与多种健康表型及血浆蛋白水平相关。
Choice of phenotype scale is critical in biobank-based G × E tests.
UK Biobank 分析显示，表型尺度选择可解释部分遗传评分与性别的交互作用。
Tumor DNA methylation subtypes and expression levels of CFISH predict response and overall survival to immunochemotherapy.
食管癌中，肿瘤DNA甲基化亚型及单核细胞相关CFISH特征与免疫化疗后的总生存期相关。
Metabolomic aging and mortality clocks based on ensemble learning identify systemic aging risk across the human life span in 18,476 individuals.
代谢组年龄加速与健康恶化、慢性病发生及全因死亡风险升高相关。
Clonal heterogeneity in human pancreatic ductal adenocarcinoma and its impact on tumor progression.
胰腺导管腺癌中，克隆多样性及MYC扩增与基底样转变、免疫反应程序减弱相关。
Early detection of gastric cancer using DNA features in red blood cells, with multicenter validation.
红细胞DNA特征分类器在多中心验证中检测胃癌的敏感度为83%-90%，I期为82%-89%。
Characterisation of Genetically-Derived Patient Clusters Highlights Genetic Heterogeneity of Inflammatory Bowel Disease
3个IBD队列中，NOD信号通路基因聚类与疾病亚型、克罗恩病行为及手术史相关，主要关联来自NOD2。
Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories.
GZMK+/GZMB+效应记忆T细胞比值与健康及病理相关衰老轨迹相关。
Breastfeeding and maternal microbial reservoirs are associated with infant gut phageome development during the first year of life.
婴儿肠道噬菌体多样性随年龄增加，喂养相关变量与特定发育阶段的噬菌体组组成相关。
Spatial omics resolves adrenergic and mesenchymal cell states in neuroblastoma.
多组学识别神经母细胞瘤间充质肿瘤细胞，高间充质基因表达与较差的无事件生存和总生存相关。
Chromatin plasticity and lineage repurposing: When gastric identity turns acidic.
评述癌前染色质状态与伪胃型亚型的发现，提示胃质子泵可能成为治疗靶点。
Chromatin accessibility trajectories reveal pre-cancerous epigenetic priming and an acid-driven immunotherapy-resistant gastric cancer subtype.
胃癌染色质可及性图谱揭示癌前预激状态，并识别出与免疫治疗耐药相关的拟胃型亚型。
Systematic transcriptomic evaluation of blastoid models of early human development.
整合人类囊胚单细胞转录组建立参考图谱，用于评估不同类囊胚模型的细胞谱系保真度。