从数据分析和研究设计的角度读新论文：数据从哪来、流程怎么走、用了什么工具、哪里值得学。
High-resolution diffusion MRI of rectal cancer ex vivo surgical specimens reveals post-treatment microstructural characteristics of tissue components
直肠癌治疗后离体标本中，扩散MRI指标与组织成分差异相关，可提供常规对比之外的微结构信息。
Real-world, digital-first delivery of GLP-1 receptor agonist therapy in women
女性数字化管理项目中，GLP-1受体激动剂治疗与体重及代谢指标改善相关，6个月留存率为91.4%。
Network pharmacology and metabolomics analysis of ginsenosides in fibrinolysis balance after hip arthroplasty
在细胞模型中，人参皂苷Rh7上调t-PA并下调PAI-1，提示其可能影响髋关节置换术后纤溶平衡。
Association of cumulative TCBI exposure with incident stroke in cardiovascular kidney metabolic syndrome stages 0 to 3
CKM 0–3期中老年人中，较高累积TCBI及高水平两时间点TCBI模式与新发卒中相关。
Clinician Use of an Artificial Intelligence-Enabled Clinical Information Platform.
AI临床信息平台使用情况因职业、专科和职业阶段而异，查询更常涉及治疗决策而非诊断。
Biological and technical spatial variation in spatial transcriptomics
提出 stipple，将空间可变捕获纳入突发式转录模型，以区分生物学变异与空间技术噪声。
Pervasive expression of early embryonic programs in cancer has stage-dependent survival impact
肿瘤的早期胚胎转录相似性与总生存期相关，关联方向因胚胎阶段及表达细胞群而异。
Auxiliary modalities add no detectable discrimination or calibration over structured EHR for 30-day COPD readmission: evidence from a leakage-audited MIMIC-IV cohort
经时间泄漏校正与再校准，多模态融合预测 COPD 30 天再入院未优于单独结构化 EHR。
2,234 attempts to harmonize a multi-platform B-cell lymphoma bulk transcriptomic dataset: ComBat is superior by cross-batch prediction quality
比较 2,234 种转录组协调化方案，提出结合多类指标与跨批次测试选择方案的流程。
Exome-wide rare variant genetic load is associated with cognition, intellectual disability and psychiatric disorders in population-based cohorts
人群队列中，基因约束加权的罕见变异遗传负荷与较低认知及多种神经精神障碍相关。
Diagnostic accuracy of deep learning for microsatellite instability prediction in gastric cancer: A systematic review and meta-analysis
深度学习预测胃癌微卫星不稳定性具有良好诊断准确性，但临床效用仍需前瞻性外部验证。
Calibration, Uncertainty, and Data Efficiency of Deep Learning Chest Radiograph Classifiers Under Cross-Dataset Distribution Shift: A Multi-Dataset Benchmark
开展胸部X线分类器跨数据集基准评测，显示源数据校准不能稳定迁移，判别能力提升不保证概率可靠。
A pangenomic method for establishing a synthetic somatic variant resource in HapMap mixtures.
提出基于泛基因组图的体细胞变异基准构建方法，用于系统评估不同技术的变异检测能力。
Prediction of immunotherapy response using live tumor fragments from routine clinical biopsies.
开发常规活检活肿瘤片段平台，以8种细胞因子构建elive index，辅助预测免疫治疗应答。
Phase 2 Trial of Icotrokinra for Patients with Ulcerative Colitis.
中重度活动性溃疡性结肠炎患者每日口服icotrokinra，3种剂量的第12周临床应答率均优于安慰剂。
Long-Acting HIV Therapy in African Adults with Adherence Challenges.
对存在依从性困难的非洲HIV感染成人，长效注射方案在48周病毒抑制方面非劣效于口服方案。
CAR T cells from code to clinic: Framing modeling approaches with current translational research goals.
提出围绕CAR T治疗转化挑战组织建模方法的框架，为模型指导的细胞治疗设计提供路线图。
Choice of phenotype scale is critical in biobank-based G × E tests.
UK Biobank 分析显示，表型尺度选择可解释部分遗传评分与性别的交互作用。
Endovascular treatment for ischemic stroke due to distal medium vessel occlusions: A nationwide multicenter registry.
远端中等血管闭塞患者接受血管内治疗联合标准药物治疗与90天无残疾率较高、症状性颅内出血风险较高相关。
RiboBA: a bias-aware probabilistic framework for robust ORF identification across diverse ribosome profiling protocols.
提出RiboBA，通过建模实验方案偏倚，改善周期性减弱的核糖体测序数据中的非经典ORF识别。