AmpliconSuite:分析癌症基因组局灶性扩增的端到端工作流
AmpliconSuite: an end-to-end workflow for analyzing focal amplifications in cancer genomes
提出 AmpliconSuite,从癌症全基因组测序中识别 ecDNA 等局灶性扩增模式。
新的分析方法、软件、数据库与实验方案:解决什么问题、怎么用、和现有方法比怎样。
AmpliconSuite: an end-to-end workflow for analyzing focal amplifications in cancer genomes
提出 AmpliconSuite,从癌症全基因组测序中识别 ecDNA 等局灶性扩增模式。
The MODNAP benchmark set for modeling ribose-based modified nucleic acid and nucleic acid-protein complexes: a case study with AlphaFold 3.
构建 MODNAP 基准集,评估修饰核酸结构预测,并揭示 AlphaFold 3 的局部定位与几何有效性问题。
RiboBA: a bias-aware probabilistic framework for robust ORF identification across diverse ribosome profiling protocols.
提出RiboBA,通过建模实验方案偏倚,改善周期性减弱的核糖体测序数据中的非经典ORF识别。
Attribute Network-based Ranking (ANeR) identifies conserved translational fingerprints of M-phase.
提出ANeR,整合异质双条件组学数据排序候选转录本,识别细胞分裂的保守翻译程序及调控因子。
Understanding when and how knowledge graphs add value to EHR-based clinical prediction across Parkinson’s disease, multiple sclerosis, and chronic pain
比较知识图谱整合策略,发现队列子图可节省计算成本,但预测收益取决于疾病。
Pocket contrastive learning and conformation fusion for robust structure-conditioned 3D molecular generation under receptor conformational variation.
提出结合口袋对比学习与参考构象特征融合的3D分子生成框架,提高受体构象变化下的稳健性。