直肠癌离体手术标本的高分辨率扩散MRI揭示治疗后组织成分的微结构特征
High-resolution diffusion MRI of rectal cancer ex vivo surgical specimens reveals post-treatment microstructural characteristics of tissue components
直肠癌治疗后离体标本中,扩散MRI指标与组织成分差异相关,可提供常规对比之外的微结构信息。
单细胞、空间组学、多组学、GWAS 与孟德尔随机化、机器学习:看清数据从哪来、分析流程怎么走、用了哪些工具。
High-resolution diffusion MRI of rectal cancer ex vivo surgical specimens reveals post-treatment microstructural characteristics of tissue components
直肠癌治疗后离体标本中,扩散MRI指标与组织成分差异相关,可提供常规对比之外的微结构信息。
Pervasive expression of early embryonic programs in cancer has stage-dependent survival impact
肿瘤的早期胚胎转录相似性与总生存期相关,关联方向因胚胎阶段及表达细胞群而异。
Auxiliary modalities add no detectable discrimination or calibration over structured EHR for 30-day COPD readmission: evidence from a leakage-audited MIMIC-IV cohort
经时间泄漏校正与再校准,多模态融合预测 COPD 30 天再入院未优于单独结构化 EHR。
Exome-wide rare variant genetic load is associated with cognition, intellectual disability and psychiatric disorders in population-based cohorts
人群队列中,基因约束加权的罕见变异遗传负荷与较低认知及多种神经精神障碍相关。
Choice of phenotype scale is critical in biobank-based G × E tests.
UK Biobank 分析显示,表型尺度选择可解释部分遗传评分与性别的交互作用。
Characterisation of Genetically-Derived Patient Clusters Highlights Genetic Heterogeneity of Inflammatory Bowel Disease
3个IBD队列中,NOD信号通路基因聚类与疾病亚型、克罗恩病行为及手术史相关,主要关联来自NOD2。