早期胚胎程序在癌症中广泛表达,其与生存的关联取决于胚胎发育阶段
Pervasive expression of early embryonic programs in cancer has stage-dependent survival impact
肿瘤的早期胚胎转录相似性与总生存期相关,关联方向因胚胎阶段及表达细胞群而异。
单细胞、空间组学、多组学、GWAS 与孟德尔随机化、机器学习:看清数据从哪来、分析流程怎么走、用了哪些工具。
Pervasive expression of early embryonic programs in cancer has stage-dependent survival impact
肿瘤的早期胚胎转录相似性与总生存期相关,关联方向因胚胎阶段及表达细胞群而异。
Tumor DNA methylation subtypes and expression levels of CFISH predict response and overall survival to immunochemotherapy.
食管癌中,肿瘤DNA甲基化亚型及单核细胞相关CFISH特征与免疫化疗后的总生存期相关。
Clonal heterogeneity in human pancreatic ductal adenocarcinoma and its impact on tumor progression.
胰腺导管腺癌中,克隆多样性及MYC扩增与基底样转变、免疫反应程序减弱相关。
Spatial omics resolves adrenergic and mesenchymal cell states in neuroblastoma.
多组学识别神经母细胞瘤间充质肿瘤细胞,高间充质基因表达与较差的无事件生存和总生存相关。
Systematic transcriptomic evaluation of blastoid models of early human development.
整合人类囊胚单细胞转录组建立参考图谱,用于评估不同类囊胚模型的细胞谱系保真度。
Disease-associated loci share properties with response eQTLs under common environmental exposures.
环境响应性eQTL与疾病风险位点具有相似调控特征,并与部分基线eQTL未能解释的疾病相关位点重合。